健保資料庫研究團隊 - 敗血症與骨質疏鬆症風險的關聯
健保資料庫研究團隊 - 敗血症與骨質疏鬆症風險的關聯
分享一篇我們團隊最近發表的論文，
📝 作者是我們中山家醫科的住院醫師李亞芳醫師，
發表在骨質疏鬆症最好的雜誌 OSTEOPOROSIS INTERNATIONAL，IF 3.8。
🔎 骨質疏鬆症其實一直是非常常見的隱形殺手，值得積極診斷跟治療。
及早診斷還是要靠骨質密度DXA的檢查，雖然這項檢查健保並不給付。
👨⚕️ 我非常建議高風險的族群自費1200元做這個骨質密度檢測。
🎉 好消息是：已經有很好的藥物，可以治療骨質疏鬆症，
而且符合條件者，健保可以終身給付。
Abstract
Summary
We conducted a large, retrospective cohort study using data from Taiwan’s National Health Insurance Research Database to evaluate whether the risk of developing osteoporosis is associated with sepsis. Our study found that adults younger than 65 years with sepsis had a significantly increased risk of developing osteoporosis.
Introduction
There have been limited studies regarding the osteoporosis risk associated with sepsis. Our purpose is to evaluate whether the risk of developing osteoporosis is associated with sepsis.
Methods
We conducted a large, retrospective cohort study using data from Taiwan’s National Health Insurance Research Database. From the insurance claims data, a total of 13,178 patients diagnosed with sepsis from 2000 to 2012 were included in the sepsis cohort, and a propensity score-matched cohort included 13,178 individuals without sepsis. To calculate the incidence of osteoporosis, both groups were followed until 2013. Cox regression analysis was performed to obtain the hazard ratios (HRs) to assess the risk of developing osteoporosis. The Kaplan–Meier method was used to estimate the cumulative incidence of osteoporosis.
Results
The overall incidences of osteoporosis (per 1,000 person-years) in the sepsis and non-sepsis groups were 10.2 and 10.7, respectively. The risk of osteoporosis significantly increased in the presence of sepsis (adjusted HR = 1.17, 95% confidence interval (CI) = 1.04–1.31). The risk of osteoporosis in the sepsis group was significantly higher than that in the non-sepsis group for young patients aged 20–49 years and patients aged 50–64 years (adjusted HR = 1.93, 95% CI = 1.08–3.44; adjusted HR = 2.01, 95% CI = 1.52–2.65, respectively). The Kaplan–Meier curves of cumulative probability also showed a significantly increased risk of osteoporosis in patients aged 20–49 years and aged 50–64 years with sepsis compared with non-sepsis (P = 0.025; P < 0.001, respectively).
Conclusion
Adults younger than 65 years with sepsis had a significantly increased risk of developing osteoporosis.
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