抗病毒藥物Paxlovid 可以減少得到新冠肺炎之後的心血管併發症

分享團隊最近的高分論文，發表在BMC Medicine

這是我們新冠肺炎系列主軸當中，除了探討疾病與疾病的相關性，更深入的探討介入能不能改變這個相關性的文章系列之一。

研究的主要發現是，抗病毒藥物Paxlovid 可以減少得到新冠肺炎之後的心血管併發症，整體而言，減少35%. 特別在年紀大的男性效果更明顯，而且染疫之後越早用效果越好。

 

Paxlovid use was associated with lower risks of cerebrovascular complications (HR = 0.65 [0.47–0.88]), arrhythmia outcomes (HR = 0.81 [0.68–0.94]), ischemic heart disease, other cardiac disorders (HR = 0.51 [0.35–0.74]) naming heart failure (HR = 0.41 [0.26–0.63]) and deep vein thrombosis (HR = 0.46 [0.24–0.87]) belonging to thrombotic disorders in AIRD patients with COVID-19. Compared with the Non-Paxlovid group, risks of major adverse cardiac events (HR = 0.56 [0.44–0.70]) and any cardiovascular outcome mentioned above (HR = 0.76 [0.66–0.86]) were lower in the Paxlovid group. Moreover, the mortality (HR = 0.21 [0.11–0.40]), admission (HR = 0.68 [0.60–0.76]), and ICU admission rates (HR = 0.52 [0.33–0.80]) were significantly lower in the Paxlovid group than in the non-Paxlovid group. Paxlovid appears to be more effective in male, older, and Black patients with AIRD. The risks of cardiovascular outcomes and severe conditions were reduced significantly with Paxlovid prescribed within the first day of COVID-19 diagnosis.