健保資料庫研究團隊 - 便秘的病人會增加以後罹患異位性皮膚炎的機會

健保資料庫研究團隊 - 便秘的病人會增加以後罹患異位性皮膚炎的機會

📝分享一篇我們團隊最近的文章。

題目：Influence of constipation on atopic dermatitis: A nationwide population‐based cohort study in Taiwan

🔎研究發現：便秘的病人會增加以後罹患異位性皮膚炎的機會，

                            可能的機轉是腸道菌相的改變。

🔎臨床應用是：碰到過敏的病人，醫生應該問一下病人有沒有便秘；

                                或許改善便秘，就有可能改善過敏。

✏️文章發表在這一期的 International Journal of clinical practice 34%, IF 2.444。

🙂令人欣慰的是：這一篇是由中山醫研所博士班學生吳孟哲主任，

                                    指導台中榮總小兒腸胃科年輕醫生發表的論文！🎉

🏆值得表揚的是：吳孟哲主任，在今年八個月以來，已經發表了八篇論文！🎉

Abstract

Background

Atopic dermatitis (AD) is the chronic inflammatory disorder that affects both in childhood and adulthood. Mounting evidence indicates that gut dysbiosis contributes to AD via the gut‐skin axis. Constipation can result in alteration of the gut microflora. The clinical impact of constipation on AD has not been researched. Therefore, we aim to assess the risk of AD in constipated patients by the population‐based cohort study.

Methods

We collected 85 554 constipated people and 85 554 people without constipation between 1999 and 2013 from the Taiwanese National Health Insurance Research Database. Propensity score analysis was administrated to match age, gender, comorbidities and medications at a ratio of 1:1. Multiple Cox regression analysis was utilised to evaluate the adjusted hazard ratio of AD. In addition, sensitivity tests and a stratified analysis were conducted.

Results

The incidence of AD was 4.9 per 1000 person‐years in the constipation group, which was higher than the rate of 2.1 per 1000 person‐years observed in the non‐constipation group. After adjustment for age, gender, comorbidities, corticosteroids, antihistamine and antibiotics, constipated people had a 2.31‐fold greater risk of AD compared with those without constipation (adjusted hazard ratio [aHR]: 2.31 (95% CI 2.17‐2.46). Moreover, constipated people had a higher likelihood of AD, regardless of gender, comorbidities, as well as the usage of corticosteroids, antihistamines and antibiotics.

Conclusion

Constipation is associated with a significantly risk factor of AD. Clinicians should be careful of the possibility of AD in constipated people. Further study is warranted to investigate the possible pathological mechanisms of this relationship.