健保資料庫研究團隊 - 乾燥症的病人長期使用奎寧可以減少冠狀動脈心臟病

健保資料庫研究團隊 - 乾燥症的病人長期使用奎寧可以減少冠狀動脈心臟病

📝 轉寄我們團隊最近發表的文章，這篇文章問了一個很好的問題，

🔎 也提供真實世界的證據：

乾燥症的病人長期使用奎寧可以減少冠狀動脈心臟病！

恭喜國軍台中總醫院風濕免疫科楊登和主任及研究團隊。🎉

題目：Cardiovascular Protection of Hydroxychloroquine in Patients with Sjögren’s Syndrome

Abstract: Sjögren’s syndrome (SS) is a chronic systemic inflammation disease with clinical presentation

of dry eye, dry mouth, and polyarthralgia. Active inflammation is associated with an increased risk of

associated arterial stiffness or subclinical atherosclerosis-related cardiovascular events. We used the

longitudinal health insurance database of Taiwan, which includes one million participants, to evaluate

the relationship between the clinical medication of hydroxychloroquine (HCQ) and the development

of coronary artery disease (CAD). In total, 1674 patients with SS receiving HCQ medication were

included after exclusion for previous CAD. Altogether, 1142 SS patients were included for evaluation

after follow-up for more than one year. After adjusting for age, gender, medications, and chronic

comorbidities, a significantly decreased hazard ratio (HR) for developing CAD was found among SS

patients with higher medication possession ratio (MPR) of HCQ (HR = 0.49, 95% confidence interval,

CI: 0.26–0.94) when compared with low MPR of HCQ. A low HR for CAD was observed in SS patients

with a high cumulative dose of at least 100,267 mg of HCQ (HR = 0.25, 95% CI: 0.09–0.66). Long-term

HCQ therapy may decrease the HR of CAD in SS patients. The significant cardiovascular protective

effect of HCQ therapy was observed in our study.

Keywords: Sjögren’s syndrome; hydroxychloroquine; inflammation; coronary artery disease;

cardiovascular event; autoimmune